Schoen FJ,等在其研究中 ，使用经戊二醛预处理的牛心包材料在植入大鼠皮下8周（56天）后，钙化程度达到200µg/mg。
欣吉特的瓣膜组织在8周大鼠皮下植入中的钙化实验结果优良，瓣膜钙化量远小于以上这些实验研究中的经抗钙化或未经抗钙化处理的瓣膜材料。并且在后续的动物实验及临床实验中均未见与钙化相关的不良事件。
1.Schoen FJ, Tsao JW, Levy RJ. Calcification of bovine pericardium used in cardiac valve bioprostheses. Implications for the mechanisms of bioprosthetic tissue mineralization. Am J Pathol. 1986 Apr;123(1):134-45.
2.Crystal M. Cunanan, Lillian Quintero, Michael N. Helmus, Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby. Patent No.: US 6214054B1, Apr.10, 2001优良优良
